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 Prof. Dr. Heinz D. Osiewacz
 Johann Wolfgang
 Inst. of Molecular Biosciences
 Max-von-Laue-Str. 9
 D-60438 Frankfurt

This  project  is  supported  through
Priority 1 (Life Sciences, Genomics
and  Biotechnology  for  Health)  of
European Union's FP6 - Contract
number: LSHM-CT-2004-512020
About MiMage

MiMage was an Integrated Project within the 6th Framework Programme of the European Commission. The project was coordinated by the Johann Wolfgang Goethe-University in Frankfurt, Germany, and was running from 1st January 2005 to 31st December 2009. The MiMage consortium consisted of 12 partners from 7 European countries (including one SME from Germany) and Canada.

The overall aim of the MiMage project was to elaborate the role of mitochondrial function in ageing and lifespan control of biological systems. Of special interest was the discovery and experimental manipulation of evolutionarily conserved mechanisms shared between invertebrate and mammalian model systems. A range of experimental organisms and cell culture systems were studied. Specific issues addressed by the project were:
  • the effect on ageing of modulating the amount of mitochondrial ROS
  • the role of molecular and cellular pathways involved in maintaining a "healthy" population of mitochondria
  • the nature and impact of age-related signalling pathways on mitochondrial functions
  • the effect of dietary restriction on mitochondrial activity
  • the impact of hitherto unknown age-related mitochondrial functions

Latest Publications

Brust D, Daum B, Breunig C, Hamann A, Kühlbrandt W, Osiewacz HD, 2010: Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. - Aging Cell 9: 761-775.
Brust D, Hamann A, Osiewacz HD, 2010: Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension. - Curr Genet 56: 225-235.
Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M, 2010: Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. - J Cell Sci 123: 917-926.
Podospora anserina
Saccharomyces cerevisiae
Drosophila melanogaster
Caenorhabditis elegans
Rattus norvegicus
Cell culture systems
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