MiMage - Role of Mitochondria in Conserved Mechanisms of Ageing

MiMage - Role of Mitochondria in
Conserved Mechanisms of Ageing


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		Coordinator

		Prof. Dr. Heinz D. Osiewacz Johann Wolfgang Goethe-University Inst. of Molecular Biosciences Max-von-Laue-Str. 9 D-60438 Frankfurt Germany

This project is supported through
Priority 1 (Life Sciences, Genomics
and Biotechnology for Health) of
European Union's FP6 - Contract
number: LSHM-CT-2004-512020

About MiMage

MiMage was an Integrated Project within the 6th Framework Programme of the European Commission. The project was coordinated by the Johann Wolfgang Goethe-University in Frankfurt, Germany, and was running from 1st January 2005 to 31st December 2009. The MiMage consortium consisted of 12 partners from 7 European countries (including one SME from Germany) and Canada.

The overall aim of the MiMage project was to elaborate the role of mitochondrial function in ageing and lifespan control of biological systems. Of special interest was the discovery and experimental manipulation of evolutionarily conserved mechanisms shared between invertebrate and mammalian model systems. A range of experimental organisms and cell culture systems were studied. Specific issues addressed by the project were:

the effect on ageing of modulating the amount of mitochondrial ROS
the role of molecular and cellular pathways involved in maintaining a "healthy" population of mitochondria
the nature and impact of age-related signalling pathways on mitochondrial functions
the effect of dietary restriction on mitochondrial activity
the impact of hitherto unknown age-related mitochondrial functions

Latest Publications

	Brust D, Daum B, Breunig C, Hamann A, Kühlbrandt W, Osiewacz HD, 2010: Cyclophilin D links programmed cell death and organismal aging in Podospora anserina. - Aging Cell 9: 761-775.

	Brust D, Hamann A, Osiewacz HD, 2010: Deletion of PaAif2 and PaAmid2, two genes encoding mitochondrial AIF-like oxidoreductases of Podospora anserina, leads to increased stress tolerance and lifespan extension. - Curr Genet 56: 225-235.

	Mai S, Klinkenberg M, Auburger G, Bereiter-Hahn J, Jendrach M, 2010: Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. - J Cell Sci 123: 917-926.